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18 April | | | Raja Casablanca | 3 - 0 | Zanaco FC | Mahmoud Benhalib (15) Mouhssine Iajour (19) Badr Benoun (77) | | |
| Stade Mohamed V | |
| 18 April | | | RSB Berkane | 2 - 0 | Generation Foot | Mohamed Azziz (34) Amdy Konte (og 75) | | |
| Stade Municipal de Berkane | |
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18 April | | | Djoliba AC | 0 - 0 | MFM FC | Stade Modibo Keita | |
| 18 April | | | Supersport United | 2 - 1 | Gor Mahia | Haron Shakava (og 60) Thabo Mnyamane (68) | | Francis Kahata (61) |
| Lucas Moripe Stadium | |
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18 April | | | Costa do Sol | 2 - 0 | Rayon Sports | Nelson Nesto (31) Leonard Tisdell (45) | | |
| Estadio do Zimpeto | |
| 18 April | | | Al Hilal Al Ubayyid | 2 - 1 | Songo | Murtada Amin (35) Nelson Ladzagla (69) | | Manuel Kambala (20) |
| Al Abyed Stadium | |
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18 April | | | Enyimba | 0 - 0 | Bidvest Wits | U J Esuene | |
| 18 April | | | Deportivo Niefang | 0 - 0 | Williamsville Athletic Club | Estadio de Bata | |
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18 April | | | Akwa United | 3 - 1 | Al-Hilal | Denis Nya (45) Michael Ibeh (49) Michael Ibeh (pen 69) | | Bisha (30) |
| Godswill Akpabio International Stadium | |
| 18 April | | | Brazzaville | 1 - 0 | Saint George | | Stade Alphonse Massamba-Debat | |
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18 April | | | Wolaitta Dicha FC | 1 - 0 | Young Africans | | Hawassa International Stadium | |
| 18 April | | | Fosa Juniors | 2 - 1 | Aduana Stars | Jose Alain (pen 2) Jose Alain (55) | | Nathaniel Asamoah (68) |
| Stade Rabemanajara | |
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17 April | | | Al Masry SC | 2 - 1 | CF Mounana | Mohamed Koffi (59) Islam Issa (75) | | Louis Ameka (66) |
| Port Said Stadium | |
| 17 April | | | USM Alger | 4 - 0 | Plateau United | Oussama Darfalou (28) Kaddour Beldjilali (44) Oussama Darfalou (49) Mohamed Benkhemessa (82) | | |
| Stade du 5 Juillet | |
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17 April | | | CR Belouizdad | 0 - 0 | ASEC Mimosas | Stade 20 Aout 1955 Algiers | |
| 17 April | | | CS La Mancha | 1 - 5 | AS Vita Club | Guy Mbenza (pen 41) | | Jean-Marc Makusu (8) Jean-Marc Makusu (55) Jean-Marc Makusu (57) Jesus Ducapel Muloko (75) Jean-Marc Makusu (88) |
| Stade Municipal Pointe-Noire | |
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08 April | | | Al-Hilal | 2 - 0 | Akwa United | El Sadig El Noor Shalash (20) Hussein Jeraf (25) | | |
| Al-Hilal Stadium | |
| 08 April | | | ASEC Mimosas | 1 - 0 | CR Belouizdad | | Stade Felix Houphouet-Boigny | |
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08 April | | | MFM FC | 0 - 1 | Djoliba AC | | Agege Stadium | |
| 08 April | | | Aduana Stars | 6 - 1 | Fosa Juniors | Elvis Opoku (9) Sam Adams (pen 34) Sam Adams (pen 41) Zakari Mumuni (63) Elvis Opoku (85) Bright Adjei (87) | | Jose Alain (3) |
| Agyeman Badu Stadium | |
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08 April | | | Gor Mahia | 1 - 0 | Supersport United | Jacques Tuyisenge (pen 79) | | |
| Kenyatta Stadium | |
| 07 April | | | Generation Foot | 3 - 1 | RSB Berkane | Amadou Dia Ndayie (50) Amadou Dia Ndayie (59) Amadou Dia Ndayie (64) | | Ayoub El Kaabi (38) |
| Stade Leopold Senghor | |
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07 April | | | Williamsville Athletic Club | 2 - 0 | Deportivo Niefang | | Stade Robert Champroux | |
| 07 April | | | Plateau United | 2 - 1 | USM Alger | King Osanga (21) Emma James (74) | | Faouzi Yaya (55) |
| Agege Stadium | |
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07 April | | | AS Vita Club | 1 - 0 | CS La Mancha | | Stade des Martyrs | |
| 07 April | | | Zanaco FC | 0 - 2 | Raja Casablanca | | | Mahmoud Benhalib (68) Zakaria Hadraf (75) |
| Nkoloma Stadium | |
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07 April | | | Saint George | 1 - 0 | Brazzaville | | Addis Ababa Stadium | |
| 07 April | | | Songo | 3 - 1 | Al Hilal Al Ubayyid | Pascoal Amorim (30) Manuel Kambala (44) Helder Pelembe (85) | | Souleymane Cisse (90) |
| Estadio do Ferroviario | |
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07 April | | | Young Africans | 2 - 0 | Wolaitta Dicha FC | Raphael Daudi (1) Emmanuel Martin (55) | | |
| Benjamin Mkapa National Stadium | |
| 06 April | | | Bidvest Wits | 1 - 1 | Enyimba | Daine Klate (3) | | Ibrahim Mustapha (5) |
| Bidvest Stadium | |
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06 April | | | Rayon Sports | 3 - 0 | Costa do Sol | Shaban Hussen (pen 44) Kevin Muhire (79) Shaban Hussen (89) | | |
| Stade Regional Nyamirambo | |
| 06 April | | | CF Mounana | 1 - 1 | Al Masry SC | Abdou Djamilou Atchabao (57) | | Ahmed Gomaa (13) |
| Stade Augustin Monedan de Sibang | |
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