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| 18 April | | | | Raja Casablanca | 3 - 0 | Zanaco FC | Mahmoud Benhalib (15)
Mouhssine Iajour (19)
Badr Benoun (77) | | |
| | Stade Mohamed V | |
| | 18 April | | | | RSB Berkane | 2 - 0 | Generation Foot | Mohamed Azziz (34)
Amdy Konte (og 75) | | |
| | Stade Municipal de Berkane | |
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| 18 April | | | | Djoliba AC | 0 - 0 | MFM FC | | Stade Modibo Keita | |
| | 18 April | | | | Supersport United | 2 - 1 | Gor Mahia | Haron Shakava (og 60)
Thabo Mnyamane (68) | | Francis Kahata (61) |
| | Lucas Moripe Stadium | |
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| 18 April | | | | Costa do Sol | 2 - 0 | Rayon Sports | Nelson Nesto (31)
Leonard Tisdell (45) | | |
| | Estadio do Zimpeto | |
| | 18 April | | | | Al Hilal Al Ubayyid | 2 - 1 | Songo | Murtada Amin (35)
Nelson Ladzagla (69) | | Manuel Kambala (20) |
| | Al Abyed Stadium | |
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| 18 April | | | | Enyimba | 0 - 0 | Bidvest Wits | | U J Esuene | |
| | 18 April | | | | Deportivo Niefang | 0 - 0 | Williamsville Athletic Club | | Estadio de Bata | |
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| 18 April | | | | Akwa United | 3 - 1 | Al-Hilal | Denis Nya (45)
Michael Ibeh (49)
Michael Ibeh (pen 69) | | Bisha (30) |
| | Godswill Akpabio International Stadium | |
| | 18 April | | | | Brazzaville | 1 - 0 | Saint George | | | Stade Alphonse Massamba-Debat | |
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| 18 April | | | | Wolaitta Dicha FC | 1 - 0 | Young Africans | | | Hawassa International Stadium | |
| | 18 April | | | | Fosa Juniors | 2 - 1 | Aduana Stars | Jose Alain (pen 2)
Jose Alain (55) | | Nathaniel Asamoah (68) |
| | Stade Rabemanajara | |
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| 17 April | | | | Al Masry SC | 2 - 1 | CF Mounana | Mohamed Koffi (59)
Islam Issa (75) | | Louis Ameka (66) |
| | Port Said Stadium | |
| | 17 April | | | | USM Alger | 4 - 0 | Plateau United | Oussama Darfalou (28)
Kaddour Beldjilali (44)
Oussama Darfalou (49)
Mohamed Benkhemessa (82) | | |
| | Stade du 5 Juillet | |
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| 17 April | | | | CR Belouizdad | 0 - 0 | ASEC Mimosas | | Stade 20 Aout 1955 Algiers | |
| | 17 April | | | | CS La Mancha | 1 - 5 | AS Vita Club | | Guy Mbenza (pen 41) | | Jean-Marc Makusu (8)
Jean-Marc Makusu (55)
Jean-Marc Makusu (57)
Jesus Ducapel Muloko (75)
Jean-Marc Makusu (88) |
| | Stade Municipal Pointe-Noire | |
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| 08 April | | | | Al-Hilal | 2 - 0 | Akwa United | El Sadig El Noor Shalash (20)
Hussein Jeraf (25) | | |
| | Al-Hilal Stadium | |
| | 08 April | | | | ASEC Mimosas | 1 - 0 | CR Belouizdad | | | Stade Felix Houphouet-Boigny | |
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| 08 April | | | | MFM FC | 0 - 1 | Djoliba AC | | | Agege Stadium | |
| | 08 April | | | | Aduana Stars | 6 - 1 | Fosa Juniors | Elvis Opoku (9)
Sam Adams (pen 34)
Sam Adams (pen 41)
Zakari Mumuni (63)
Elvis Opoku (85)
Bright Adjei (87) | | Jose Alain (3) |
| | Agyeman Badu Stadium | |
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| 08 April | | | | Gor Mahia | 1 - 0 | Supersport United | | Jacques Tuyisenge (pen 79) | | |
| | Kenyatta Stadium | |
| | 07 April | | | | Generation Foot | 3 - 1 | RSB Berkane | Amadou Dia Ndayie (50)
Amadou Dia Ndayie (59)
Amadou Dia Ndayie (64) | | Ayoub El Kaabi (38) |
| | Stade Leopold Senghor | |
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| 07 April | | | | Williamsville Athletic Club | 2 - 0 | Deportivo Niefang | | | Stade Robert Champroux | |
| | 07 April | | | | Plateau United | 2 - 1 | USM Alger | King Osanga (21)
Emma James (74) | | Faouzi Yaya (55) |
| | Agege Stadium | |
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| 07 April | | | | AS Vita Club | 1 - 0 | CS La Mancha | | | Stade des Martyrs | |
| | 07 April | | | | Zanaco FC | 0 - 2 | Raja Casablanca | | | | Mahmoud Benhalib (68)
Zakaria Hadraf (75) |
| | Nkoloma Stadium | |
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| 07 April | | | | Saint George | 1 - 0 | Brazzaville | | | Addis Ababa Stadium | |
| | 07 April | | | | Songo | 3 - 1 | Al Hilal Al Ubayyid | Pascoal Amorim (30)
Manuel Kambala (44)
Helder Pelembe (85) | | Souleymane Cisse (90) |
| | Estadio do Ferroviario | |
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| 07 April | | | | Young Africans | 2 - 0 | Wolaitta Dicha FC | Raphael Daudi (1)
Emmanuel Martin (55) | | |
| | Benjamin Mkapa National Stadium | |
| | 06 April | | | | Bidvest Wits | 1 - 1 | Enyimba | | Daine Klate (3) | | Ibrahim Mustapha (5) |
| | Bidvest Stadium | |
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| 06 April | | | | Rayon Sports | 3 - 0 | Costa do Sol | Shaban Hussen (pen 44)
Kevin Muhire (79)
Shaban Hussen (89) | | |
| | Stade Regional Nyamirambo | |
| | 06 April | | | | CF Mounana | 1 - 1 | Al Masry SC | | Abdou Djamilou Atchabao (57) | | Ahmed Gomaa (13) |
| | Stade Augustin Monedan de Sibang | |
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